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NITROUS OXIDE


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicityyes
Allergies & immunotoxicity no information
Contamination concerns: none
Other MODERATE concerns: Neurotoxicity
Other LOW concerns: Organ system toxicity (non-reproductive), Ecotoxicology, Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Synonym(s): DINITROGEN MONOXIDE; NITROGEN OXIDE; DINITROGEN OXIDE; NITROGEN OXIDE (N2O) ; DINITROGEN MONOXIDE; FACTITIOUS AIR; HYPONITROUS ACID ANHYDRIDE; LAUGHING GAS; NITROUS OXIDE (ACGIH:OSHA)

Developmental/reproductive toxicity

Type of Concern Reference
Possible human developmental toxicantCalifornia EPA Proposition 65
Human reproductive toxicant - moderate evidenceCHE Toxicant and Disease Database

Neurotoxicity

Type of Concern Reference
Moderate evidence of human neurotoxicityCHE Toxicant and Disease Database
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Organ system toxicity (non-reproductive)

Type of Concern Reference
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)National Library of Medicine HazMap
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Ecotoxicology

Type of Concern Reference
Suspected to be an environmental toxin and be persistent or bioaccumulative (uncertainty in environmental toxicity or persistence/bioaccumulation)Environment Canada Domestic Substance List
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Occupational hazards

Type of Concern Reference
Single case study detailing occupational hazardsFrazier , L, 1998

Data gaps

Type of Concern Reference
Not assessed for safety in cosmetics by industry panel
17,415 studies in PubMed science library may include information on the toxicity of this chemical see search results -> PubMed

Persistence and bioaccumulation

Type of Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Multiple, additive exposure sources

Type of Concern Reference
Designated as safe for general or specific, limited use in food FDA Food Additive Status
Designated as safe for general or specific, limited use in food FDA Everything Added to Food

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
FDA Food Additive StatusNITROUS OXIDE• MISC
• GRAS
• Propellant for dairy & veg-fat toppings in pressurized containers - CFR184.1545
Association of Occupational and Environmental ClinicsNITROUS OXIDE• o
CHE Toxicant and Disease DatabaseNITROUS OXIDEPeripheral neuropathy - Good
CHE Toxicant and Disease DatabaseNITROUS OXIDEReduced Fertility - Female (infertility and subfertility) - Good
FDA Everything Added to FoodNITROUS OXIDE• ASP
Environment Canada Domestic Substance ListNITROGEN OXIDE (N2O),,,Y-Persistent,,U-AquaticTox,,,,
National Library of Medicine HazMapNITROUS OXIDESD: No;NT: Sensorimotor Neuropathy;OP: Simple Asphyxiant;TL: 50 ppm;FL: 0: will not burn;MA: 100 ppm;
California EPA Proposition 65NITROUS OXIDEdevelopmental
Frazier , L, 1998NITROUS OXIDEReproductive Toxicity Hazards: suspected

references
government/industry list/academic study reference
FDA Food Additive StatusFDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
Association of Occupational and Environmental ClinicsAOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
CHE Toxicant and Disease DatabaseCHE (The Collaborative on Health and the Environment). 2006. Toxicant and Disease Database.
FDA Everything Added to FoodFDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
National Library of Medicine HazMapNLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
California EPA Proposition 65California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
Scorecard.org Toxicity InformationFrazier , L. and M. L. Hage (eds.). Reproductive Hazards of the Workplace, Wiley Europe, 1998. Table 10 (Partial List of Reproductive Toxicants) available at http://www.pharmacy.ohio-state.edu/homepage/safety/chemhygiene_table_repro.pdf.

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