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HEXANE
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About the ratings
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal DisclaimerSynonym(s): N-HEXANE; ESANI (ITALIAN) ; GETTYSOLVE-B; HEKSAN (POLISH) ; HEXANEN (DUTCH) ; HEXYL HYDRIDE; N-HEXANE; N-HEXANE (ACGIH:OSHA) ; NCI-C60571
Neurotoxicity | ||
|---|---|---|
| Type of Concern | Reference | |
| Strong evidence of human neurotoxicity | Chemicals known to be neurotoxic to humans | |
| Moderate evidence of human neurotoxicity | CHE Toxicant and Disease Database | |
Organ system toxicity (non-reproductive) | ||
|---|---|---|
| Type of Concern | Reference | |
| Known human respiratory toxicant | EPA Hazardous Air Pollutants | |
| Classified as a high human health priority | Environment Canada Domestic Substance List | |
| Classified as expected to be toxic or harmful | Environment Canada Domestic Substance List | |
| show more | ||
Developmental/reproductive toxicity | ||
|---|---|---|
| Type of Concern | Reference | |
| Limited evidence of developmental toxicity | European Union - Classification & Labelling | |
| Human nervous system toxicant - moderate evidence | Chemicals known to be neurotoxic to humans | |
| Possible human reproductive or developmental toxin | Environment Canada Domestic Substance List | |
Occupational hazards | ||
|---|---|---|
| Type of Concern | Reference | |
| Allowed workplace exposures restricted to low doses | European Union - Classification & Labelling | |
| show more | ||
Ecotoxicology | ||
|---|---|---|
| Type of Concern | Reference | |
| Wildlife and environmental toxicity | European Union - Classification & Labelling | |
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Data gaps | ||
|---|---|---|
| Type of Concern | Reference | |
| Not assessed for safety in cosmetics by industry panel | ||
| 9,409 studies in PubMed science library may include information on the toxicity of this chemical see search results -> | PubMed | |
Miscellaneous | ||
|---|---|---|
| Type of Concern | Reference | |
| Occupational hazards related to handling | European Union - Classification & Labelling | |
Persistence and bioaccumulation | ||
|---|---|---|
| Type of Concern | Reference | |
| Not suspected to be persistent | Environment Canada Domestic Substance List | |
| show more | ||
Multiple, additive exposure sources | ||
|---|---|---|
| Type of Concern | Reference | |
| Designated as safe for general or specific, limited use in food | FDA Food Additive Status | |
| Designated as safe for general or specific, limited use in food | FDA Everything Added to Food | |
Government, industry, academic studies and classifications |
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|---|---|---|
| government/industry list/academic study | appears on list as | classification(s) |
| European Union - Classification & Labelling | N-HEXANE | F; R11;Repr. Cat. 3; R62;Xn; R48/20-65 Xi; R38 R67 N; R51-53 |
| FDA Food Additive Status | HEXANE | • SOLV • REG • 25 ppm as residue - In spice oleoresins (173.270) • 2.2% by weight - As residue in hops extract • extract added before or during cooking of beer -173.270 • MISC • REG • 25 ppm - In modified hop extract for beer - CFR172.560 • MISC • REG • 5 ppm as residue |
| Association of Occupational and Environmental Clinics | HEXANE | • S |
| Association of Occupational and Environmental Clinics | HEXANE | • S |
| CHE Toxicant and Disease Database | HEXANE | Spasticity/Myoclonus - Good |
| FDA Everything Added to Food | HEXANE | • ASP |
| Environment Canada Domestic Substance List | HEXANE | Y-Categorization,Y-Human health,High-Health Priority,,,Y-AquaticTox,,Developmental,,Reproductive |
| European Union - Banned or Restricted in Cosmetics | HEXANE | Banned in EU Cosmetics |
| EPA Hazardous Air Pollutants | HEXANE | Hazardous Air Pollutant |
| National Library of Medicine HazMap | N-HEXANE | SD: Yes;NT: Motor Neuropathy;PE: 500 ppm;TL: 50 ppm;BE: 2,5-Hexanedione (free) in urine = 0.4 mg/L end of shift at end of workweek;;FL: 3: may ignite at ambient temperature;ID: 1100 ppm;OH: 248 ppm;OL: 65 ppm;MA: 50 ppm; |
| EPA Categorized List of Inert Pesticide Ingredients | HEXANE | List 1 Inert |
| Chemicals known to be neurotoxic to humans | N-HEXANE | known to be neurotoxic to humans |
| EPA Toxic Release Inventory PBTs | HEXANE | Toxic under the EPA's Toxics Release Inventory |
| Frazier , L, 1998 | N-HEXANE | Reproductive Toxicity Hazards: suspected |
references |
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|---|---|---|
| government/industry list/academic study | reference | |
| European Union - Classification & Labelling | CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP. | |
| FDA Food Additive Status | FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006. | |
| Association of Occupational and Environmental Clinics | AOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation. | |
| CHE Toxicant and Disease Database | CHE (The Collaborative on Health and the Environment). 2006. Toxicant and Disease Database. | |
| FDA Everything Added to Food | FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition. | |
| Environment Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. | |
| European Union - Banned or Restricted in Cosmetics | EC (European Commission of the European Union). 1999-2006. Enterprise Directorate-General Pharmaceuticals and Cosmetics. The rules governing cosmetic products in the European Union, Volume 1, "Cosmetics legislation." | |
| EPA Hazardous Air Pollutants | EPA (U.S. Environmental Protection Agency). 2005. Office of Air. The 112(b)1 Hazardous Air Pollutants List (as modified). Last modified: 12 Dec 2005. | |
| National Library of Medicine HazMap | NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents. | |
| EPA Categorized List of Inert Pesticide Ingredients | EPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients. | |
| Chemicals known to be neurotoxic to humans | Grandjean P and PJ Landrigan. 2006. Developmental neurotoxicity of industrial chemicals. Lancet. 2006 Dec 16;368(9553):2167-78. | |
| EPA Toxic Release Inventory PBTs | EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule. | |
| Scorecard.org Toxicity Information | Frazier , L. and M. L. Hage (eds.). Reproductive Hazards of the Workplace, Wiley Europe, 1998. Table 10 (Partial List of Reproductive Toxicants) available at http://www.pharmacy.ohio-state.edu/homepage/safety/chemhygiene_table_repro.pdf. | |
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